دانلود مقاله Electrospinning, mechanical properties and cell behavior study of chitosan/PVA nanofibers
دانلود مقاله
Electrospinning, mechanical properties and cell behavior study of chitosan/PVA nanofibers
نویسنده :
Mojtaba Koosha, Hamid Mirzadeh
فرمت:pdf
چکیده :
Electrospinning process has been widely used to produce nanofibers from polymer blends.
Poly (vinyl alcohol) (PVA) and chitosan (CS) have numerous biomedical applications such as
wound healing and tissue engineering. Nanofibers of CS/PVA have been prepared by many
works, however, a complete physic-chemical and mechanical characterization as well as cell
behavior has not been reported. In this study, PVA and CS/PVA blend solutions in acetic acid
70% with different volume ratios (30/70, 50/50 and 70/30) were electrospun in constant
electrospinning process parameters. The structure and morphology of nanofibrous mats
were characterized by SEM, FTIR and XRD methods. The best nanofibrous mat was achieved
from the CS/PVA 30/70 blend solution regarding the electrospinning throughput. The
dynamic mechanical thermal analysis (DMTA) of PVA and CS/PVA 30/70 nanofibrous mats
were measured which were not considered in the previous studies. DMTA results in
accordance to the DSC analysis, approved the partial compatibility between the two
polymers, while a single glass transition temperature was not observed for the blend. The
tensile strength of PVA and CS/PVA nanofibers were also reported. Results of cell behavior
study indicated that the heat stabilized nanofibrous mat CS/PVA 30/70 was able to support
the attachment and proliferation of the fibroblast cells.